Physiological closed-loop control (PCLC) systems are a key enabler for automation and
clinician support in medicine, including, but not limited to, patient monitoring, diagnosis …

This letter presents an extended moving horizon observer to estimate both the states and the
pharmacodynamic (PD) parameters of an anesthesia model, based on real data. The inputs …

This letter presents a novel approach to assure hemodynamic safety in closed-loop
controlled critical care. The approach is equipped with safety-preserving control based on …

This letter investigates the potential of model-based extended Kalman filtering (EKF) for
hemodynamic monitoring in a hemorrhage resuscitation-sedation case study. To the best of …

This paper presents a robust closed-loop control approach to fluid resuscitation in patients
with hemorrhagic blood loss. A unique strength of the proposed approach is its robustness …

This work studies the classical pharmacokinetic-pharmacodynamic (PK-PD) model of
Propofol for total intravenous anesthesia in response to intraoperative blood loss. Anesthetic …

This paper presents a virtual patient generator (VPG) intended to be used for preclinical in
silico evaluation of autonomous vasopressor administration algorithms in the setting of …

A novel control strategy is proposed to enable uncertainty minimization through knowledge
infusion into the closed loop. The developed methodology aims the application of predictive …

In this paper, a novel control methodology is presented to regulate the complex anesthetic-
hemodynamic interaction during general anesthesia by means of predictive control …

The treatment of combat casualties frequently involves infusion of multiple drugs (eg
sedatives, opioids and vasopressors) in addition to fluid resuscitation. Usually, fluid …