Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects
of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by …

Cancer refers to the division of abnormal cells at an uncontrollable rate that possesses the
ability to infiltrate and destroy normal tissues. It frequently spreads to normal tissues …

Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …

The synthesis and pharmacological activity of a new series of isoxazolylpyrimidines as
sigma-2 receptor (σ2R) ligands are reported. Modification of a new hit retrieved in an HTS …

Abstract The σ-2 receptor (S2R) complex has been implicated in CNS disorders ranging
from anxiety and depression to neurodegenerative disorders such as Alzheimer's disease …

Abstract Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate
sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were …

The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …