Imaging as a (pre) clinical tool in parasitology

CM de Korne, L van Lieshout, FWB van Leeuwen… - Trends in …, 2023 - cell.com
Imaging of parasites is central to diagnosis of many parasitic diseases and has thus far
played an important role in the development of antiparasitic strategies. The development of …

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

GA Dziwornu, HD Attram, S Gachuhi… - RSC Medicinal …, 2020 - pubs.rsc.org
Globally, schistosomiasis threatens more than 700 million lives, mostly children, in poor
localities of tropical and sub-tropical areas with morbidity due to acute and chronic …

[HTML][HTML] Anthelmintic activity in vitro and in vivo of Baccharis trimera (Less) DC against immature and adult worms of Schistosoma mansoni

RN de Oliveira, VLG Rehder, ASS Oliveira… - Experimental …, 2014 - Elsevier
Although its efficiency against all Schistosoma species, praziquantel (PZQ) shows low
efficacy against schistosomula and juvenile stages. The potential for development of …

Juglone:“A novel immunomodulatory, antifibrotic, and schistosomicidal agent to ameliorate liver damage in murine schistosomiasis mansoni”

RG Khalil, AM Ibrahim, HH Bakery - International Immunopharmacology, 2022 - Elsevier
Schistosomiasis remains one of the world's leading health concerns, affecting millions. The
granulomatous reaction is the most significant immunopathological change associated with …

Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis

H Lyu, PA Petukhov, PR Banta, A Jadhav… - ACS infectious …, 2020 - ACS Publications
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people. Chemotherapy for schistosomiasis relies exclusively on praziquantel …

Anti‐inflammatory, antioxidant, anti‐fibrotic and schistosomicidal properties of plumbagin in murine schistosomiasis

HH Bakery, GA Allam, ASA Abuelsaad… - Parasite …, 2022 - Wiley Online Library
Schistosomiasis is still a major health problem affecting nearly 250 million people worldwide
and causes approximately 280,000 deaths per year. The disease causes a serious …

Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni

DA Yones, DM Badary, HMB Sayed… - BioMed research …, 2016 - Wiley Online Library
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery
of new antischistosomal agents is of high priority in research. This work reported the in vitro …

Antischistosomal Activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa Plant Extracts on Hamster Infected with Schistosoma haematobium

YAJ Fadladdin - BioMed Research International, 2021 - Wiley Online Library
World Health Organization (WHO) has approved only one treatment for schistosomiasis,
praziquantel (PZQ), but some poor efficacy was noticed in patients during the early stage of …

In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum

X Wang, D Yu, C Li, T Zhan, T Zhang, H Ma, J Xu… - Parasites & vectors, 2019 - Springer
Background Schistosomiasis is a debilitating neglected tropical disease that affects
approximately 190 million people around the world. Praziquantel (PZQ) is the only drug …

High Selectivity of 8-Hydroxyquinoline on Leishmania (Leishmania) and Leishmania (Viannia) Species Correlates with a Potent Therapeutic Activity In Vivo

SKS Lima, JA Jesus, C Raminelli, MD Laurenti… - Pharmaceuticals, 2023 - mdpi.com
Leishmaniasis is a neglected disease caused by protozoa of the genus Leishmania, which
causes different clinical manifestations. Drugs currently used in the treatment such as …