Novel insights on the pulmonary vascular consequences of COVID-19

F Potus, V Mai, M Lebret, S Malenfant… - … of Physiology-Lung …, 2020 - journals.physiology.org
In the last few months, the number of cases of a new coronavirus-related disease (COVID-
19) rose exponentially, reaching the status of a pandemic. Interestingly, early imaging …

[HTML][HTML] Mechanisms of disease: pulmonary arterial hypertension

RT Schermuly, HA Ghofrani, MR Wilkins… - Nature Reviews …, 2011 - nature.com
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

Pediatric pulmonary hypertension: guidelines from the American heart association and American thoracic society

SH Abman, G Hansmann, SL Archer, DD Ivy, I Adatia… - Circulation, 2015 - Am Heart Assoc
Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Cellular and molecular pathobiology of pulmonary arterial hypertension

M Humbert, NW Morrell, SL Archer… - Journal of the American …, 2004 - jacc.org
Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …

Pulmonary arterial hypertension

HW Farber, J Loscalzo - New England Journal of Medicine, 2004 - Mass Medical Soc
This review of the mechanism of pulmonary hypertension is focused on pulmonary arterial
hypertension, a disorder that can be idiopathic or can occur in association with other …

Inflammation in pulmonary arterial hypertension

LC Price, SJ Wort, F Perros, P Dorfmüller, A Huertas… - Chest, 2012 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …

Molecular pathogenesis of pulmonary arterial hypertension

M Rabinovitch - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …

The metabolic theory of pulmonary arterial hypertension

R Paulin, ED Michelakis - Circulation research, 2014 - Am Heart Assoc
Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …

Inflammation, growth factors, and pulmonary vascular remodeling

PM Hassoun, L Mouthon, JA Barberà… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental
pulmonary hypertension (PH) and are increasingly recognized as major pathogenic …

Pathologic assessment of vasculopathies in pulmonary hypertension

GG Pietra, F Capron, S Stewart, O Leone… - Journal of the American …, 2004 - jacc.org
Pulmonary arterial hypertension (PAH) includes various forms of pulmonary hypertension of
different etiology but similar clinical presentation and functional derangement …