Notable changes in lung cancer epidemiology and prevention have occurred over the past
decade owing to changes in smoking patterns, groundbreaking advances in our …

Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …

Lung cancer is the leading cause of cancer death in the United States and around the world.
Almost as many Americans die of lung cancer every year than die of prostate, breast, and …

Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …

Carcinoma of the lung is currently the leading cause worldwide of death due to cancer. The
disease has become an epidemic as incidence rates and lung cancer deaths have risen …

Background The objective of this study was to summarize the published literature
concerning the epidemiology of lung cancer. Methods A narrative review of published …

In the United States, the 20th century witnessed the emergence of a lung cancer epidemic
that peaked and began to decline by the century's end, a decline that continues today …

Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25. 1 region, which …

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and
are suggested to be related to cancer risk. However, epidemiologic findings have been …