Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

AJ Van Der Lely, M Tschop, ML Heiman… - Endocrine …, 2004 - academic.oup.com
Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-
releasing activity. This activity is mediated by the activation of the so-called GH …

Ghrelin—a hormone with multiple functions

M Korbonits, AP Goldstone, M Gueorguiev… - Frontiers in …, 2004 - Elsevier
Ghrelin is brain-gut peptide with growth hormone-releasing and appetite-inducing activities.
It is mainly secreted from the stomach mucosa but it is also expressed widely in different …

A receptor in pituitary and hypothalamus that functions in growth hormone release

AD Howard, SD Feighner, DF Cully, JP Arena… - Science, 1996 - science.org
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the
pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone …

Neuroendocrine control of growth hormone secretion

EE Muller, V Locatelli, D Cocchi - Physiological reviews, 1999 - journals.physiology.org
The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat

MG Willesen, P Kristensen, J Rømer - Neuroendocrinology, 1999 - karger.com
Growth hormone secretagogues (GHS) are small, synthetic compounds which have the
potential of releasing growth hormone (GH) from the pituitary. The mechanism of action of …

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

G Muccioli, M Tschöp, M Papotti, R Deghenghi… - European journal of …, 2002 - Elsevier
Ghrelin, a 28-amino acid acylated peptide predominantly produced by the stomach, displays
strong growth hormone (GH)-releasing activity mediated by the hypothalamus–pituitary GH …

Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues

S Lall, LYC Tung, C Ohlsson, JO Jansson… - Biochemical and …, 2001 - Elsevier
Growth hormone secretagogues (GHSs) stimulate growth hormone (GH) secretion, which is
lipolytic. Here we compared the effects of twice daily sc treatment of GH and the GHS …

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following …

SL Dickson, SM Luckman - Endocrinology, 1997 - academic.oup.com
In this study we investigated the neurochemical identity of the arcuate cells activated
following GH-releasing peptide-6 (GHRP-6) injection by comparing, on consecutive …

Steroid sulfatase inhibitors for estrogen-and androgen-dependent cancers

A Purohit, PA Foster - Journal of Endocrinology, 2012 - joe.bioscientifica.com
We have recently demonstrated the existence of a neuromodulatory regulation of prolactin
secretion by the opioid system showing a paradoxical opioid-induced prolactin suppression …

Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat

PA Bennett, GB Thomas, AD Howard… - …, 1997 - academic.oup.com
Synthetic GH secretagogues (GHSs) act via a receptor (GHS-R) distinct from that for GH-
releasing hormone (GHRH). We have studied the hypothalamic expression and regulation …