Abstract Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and
environmental factors, and their interactions. The Collaborative Study on the Genetics of …

Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

De novo mutations and copy number deletions in NRXN1 (2p16. 3) pose a significant risk for
schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a …

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …

Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet
their molecular implications remain underexplored. Neuroimmune interactions, particularly …

Assessing and responding to threats is vital in everyday life. Unfortunately, many mental
illnesses involve impaired risk assessment, affecting patients, families, and society. The …

Given the large number of genes significantly associated with risk for neuropsychiatric
disorders, a critical unanswered question is the extent to which diverse mutations …

Recent genome-wide association studies (GWAS) and whole-exome sequencing of
neuropsychiatric disorders, especially schizophrenia, have identified a plethora of common …

The development of autism spectrum disorders (ASDs) involves both environmental factors
such as maternal diabetes and genetic factors such as neuroligins (NLGNs). NLGN2 and …

Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study
human neurological disorders by recapitulating human-specific disease mechanisms. In …