Chemistries of bifunctional PROTAC degraders
C Cao, M He, L Wang, Y He, Y Rao - Chemical Society Reviews, 2022 - pubs.rsc.org
Proteolysis targeting chimeras (PROTACs) technology is a novel and promising therapeutic
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
strategy using small molecules to induce ubiquitin-dependent degradation of proteins. It has …
EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate cancer—2020 update. Part 1: screening, diagnosis, and local treatment with curative intent
N Mottet, RCN van den Bergh, E Briers… - European urology, 2021 - Elsevier
Objective To present a summary of the 2020 version of the European Association of Urology
(EAU)-European Association of Nuclear Medicine (EANM)-European Society for …
(EAU)-European Association of Nuclear Medicine (EANM)-European Society for …
Focal boost to the intraprostatic tumor in external beam radiotherapy for patients with localized prostate cancer: results from the FLAME randomized phase III trial
LGW Kerkmeijer, VH Groen, FJ Pos… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE This study investigates whether focal boosting of the macroscopic visible tumor
with external beam radiotherapy increases biochemical disease-free survival (bDFS) in …
with external beam radiotherapy increases biochemical disease-free survival (bDFS) in …
Prostate-only versus whole-pelvic radiation therapy in high-risk and very high-risk prostate cancer (POP-RT): outcomes from phase III randomized controlled trial
PURPOSE We report the clinical outcomes of a randomized trial comparing prophylactic
whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate …
whole-pelvic nodal radiotherapy to prostate-only radiotherapy (PORT) in high-risk prostate …
Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non …
A Kneebone, C Fraser-Browne, GM Duchesne… - The Lancet …, 2020 - thelancet.com
Background Adjuvant radiotherapy has been shown to halve the risk of biochemical
progression for patients with high-risk disease after radical prostatectomy. Early salvage …
progression for patients with high-risk disease after radical prostatectomy. Early salvage …
Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international …
DH Brand, AC Tree, P Ostler, H van der Voet… - The Lancet …, 2019 - thelancet.com
Background Localised prostate cancer is commonly treated with external-beam
radiotherapy. Moderate hypofractionation has been shown to be non-inferior to conventional …
radiotherapy. Moderate hypofractionation has been shown to be non-inferior to conventional …
[HTML][HTML] Head-to-head comparison of transrectal ultrasound-guided prostate biopsy versus multiparametric prostate resonance imaging with subsequent magnetic …
M van der Leest, E Cornel, B Israel, R Hendriks… - European urology, 2019 - Elsevier
Background There is growing interest to implement multiparametric magnetic resonance
imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected …
imaging (mpMRI) and MR-guided biopsy (MRGB) for biopsy-naïve men with suspected …
Reporting and interpreting decision curve analysis: a guide for investigators
Context Urologists regularly develop clinical risk prediction models to support clinical
decisions. In contrast to traditional performance measures, decision curve analysis (DCA) …
decisions. In contrast to traditional performance measures, decision curve analysis (DCA) …
[HTML][HTML] Epidemiology of prostate cancer
P Rawla - World journal of oncology, 2019 - ncbi.nlm.nih.gov
Prostate cancer is the second most frequent cancer diagnosis made in men and the fifth
leading cause of death worldwide. Prostate cancer may be asymptomatic at the early stage …
leading cause of death worldwide. Prostate cancer may be asymptomatic at the early stage …
Global trends and prostate cancer: a review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location
HE Taitt - American journal of men's health, 2018 - journals.sagepub.com
Although research has reported that prostate cancer (PCa) incidence and mortality rates are
among the highest for African Americans, the data is inconclusive regarding PCa rates in …
among the highest for African Americans, the data is inconclusive regarding PCa rates in …