Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of
major depressive disorder. We investigated the effect of chronic social defeat stress, a …

Several lines of evidence suggest that stress induces the neurovascular dysfunction
associated with increased blood–brain barrier (BBB) permeability, which could be an …

Resilience is the process that allows individuals to adapt to adverse conditions and recover
from them. This process is favored by individual qualities that have been amply studied in …

The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Recovery from major depressive disorder is difficult, particularly in patients who are
refractory to antidepressant treatments. To examine factors that regulate recovery, we …

Background Depression is a recurrent and devastating mental disease that is highly
prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is …

Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …

Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition
characterized by depressed mood, social isolation and anhedonia. It will affect 20% of …