Background Because of the disability associated with surgery for anal fissure and the risk of
incontinence, medical alternatives for surgery have been sought. Most recently …

Nitric oxide is an intracellular and intercellular messenger with important functions in a
number of physiologic and pathobiologic processes within gastroenterology and …

Background Anal fissure has a very large number of treatment options. The choice is difficult.
In an effort to assist in that, choice presented here is a systematic review and meta-analysis …

Background and Methods Lateral internal sphincterotomy, the most common treatment for
chronic anal fissure, may cause permanent injury to the anal sphincter, which can lead to …

Children with neurodevelopmental disabilities such as cerebral palsy (CP), spina bifida, or
inborn errors of metabolism frequently have associated gastrointestinal problems. These …

BACKGROUND Topical application of glyceryl trinitrate (GTN) ointment heals chronic anal
fissures, providing an alternative to the traditional first line treatment of surgical …

The American Society of Colon and Rectal Surgeons is dedicated to ensuring high-quality
patient care by advancing the science, prevention, and management of disorders and …

PURPOSE: This was a multicenter, randomized, controlled trial to compare the effectiveness
of topical nitroglycerin with internal sphincterotomy in the treatment of chronic anal fissure …

Anorectal complaints are very common and are caused by a variety of mostly benign
anorectal disorders. Many anorectal conditions may be successfully treated by primary care …

PURPOSE: Topical glyceryl trinitrate heals anal fissures, but a majority of patients
experience headache. Topical gels of the calcium channel blocker diltiazem and the …