A biochemistry‐oriented drug design: synthesis, anticancer activity, enzymes inhibition, molecular docking studies of novel 1, 2, 4-triazole derivatives
K Yuriy, G Kusdemir, P Volodymyr… - Journal of …, 2024 - Taylor & Francis
In this study, we researched the reactions of 5-(5-bromofuran-2-yl)-4-methyl-1, 2, 4-triazole-3-
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …
thiol and 5-thiophene-(3-ylmethyl)-4R-1, 2, 4-triazole-3-thiols with some halogen-containing …
Benzotriazole-oxadiazole hybrid Compounds: Synthesis, anticancer Activity, molecular docking and ADME profiling studies
Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized
using both conventional method and ultrasound sonication (US) as an environmentally …
using both conventional method and ultrasound sonication (US) as an environmentally …
Synthesis, characterization and bioactivity of novel 8-hydroxyquinoline derivatives: Experimental, molecular docking, DFT and POM analyses
M Rbaa, S Haida, B Tuzun, A El Hassane… - Journal of Molecular …, 2022 - Elsevier
In this present research work, new 8-hydroxyquinoline derivatives were synthesized and
their molecular structures were confirmed by the 1 H NMR, 13 C NMR, IR and elemental …
their molecular structures were confirmed by the 1 H NMR, 13 C NMR, IR and elemental …
Design, syntheses, theoretical calculations, MM-GBSA, potential anti-cancer and enzyme activities of novel Schiff base compounds
H Yalazan, D Koç, F Aydın Kose… - Journal of …, 2024 - Taylor & Francis
In this study, new Schiff base compounds (SB-F-OH, SB-Cl-OH and SB-Br-OH) were derived
from chalcone-derived amine compounds containing halogen groups and 4 …
from chalcone-derived amine compounds containing halogen groups and 4 …
Synthesis, characterization, molecular modeling against EGFR target and ADME/T analysis of novel purine derivatives of sulfonamides
A novel series of purine derivatives containing sulfonamide moiety were synthesized in
good yield by the single-step reaction method. The purity of compounds was determined by …
good yield by the single-step reaction method. The purity of compounds was determined by …
Synthesis, spectroscopic characterization, antibacterial activity, and computational studies of novel pyridazinone derivatives
In this work, a novel series of pyridazinone derivatives (3–17) were synthesized and
characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All …
characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All …
Crystal structure and Hirshfeld surface analysis of 5-amino-5′-bromo-2′-oxo-2, 3-dihydro-1H-spiro [imidazo [1, 2-a] pyridine-7, 3′-indoline]-6, 8-dicarbonitrile …
In the title compound, C16H11BrN6O· 2C2H6OS, the 1, 2, 3, 7-tetrahydroimidazo [1, 2-a]
pyridine ring system and the oxindole moiety are both nearly planar [maximum deviations …
pyridine ring system and the oxindole moiety are both nearly planar [maximum deviations …
Improvement of photochemical and enzyme inhibition properties of new BODIPY compound by conjugation with cisplatin
In this study, new BODIPY complexes were synthesized, characterized and investigated for
their some metabolic enzyme inhibition and photophysicochemical properties. BODIPY …
their some metabolic enzyme inhibition and photophysicochemical properties. BODIPY …
The Evaluation of Anticancer, Antioxidant, Antidiabetic and Anticholinergic Potentials of Endemic Rhabdosciadium microcalycinum Supported by Molecular Docking …
MK Erdogan, R Gundogdu, Y Yapar… - …, 2022 - Wiley Online Library
Lung cancer is the most common cancer worldwide and the leading cause of cancer‐related
death. Plant‐derived natural products and compounds are an inspiring source of …
death. Plant‐derived natural products and compounds are an inspiring source of …
[PDF][PDF] Crystal structure and Hirshfeld surface analysis of 1-(tert-butylamino)-3-mesitylpropan-2-ol hemihydrate
The title compound, 2C16H27NO· H2O, crystallizes in the monoclinic P21/c space group
with two independent molecules (A and B) in the asymmetric unit. In the crystal, molecules A …
with two independent molecules (A and B) in the asymmetric unit. In the crystal, molecules A …