Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Rational drug design implies usage of molecular modeling techniques such as
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …

Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …

Herein, a new wave of bis ([1, 2, 4] triazolo)[4, 3-a: 3', 4'-c] quinoxaline derivatives have been
successfully designed and synthesised. The synthesised derivatives were biologically …

In the current study, we designed and synthesized a series of new quinoline derivatives 10a-
p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary …

Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the
development of new therapeutic agents against antibiotic resistance is in urgent demand …

Targeting the signaling pathway of the Vascular endothelial growth factor receptor-2 is a
promising approach that has drawn attention in the quest to develop novel anti-cancer drugs …

Vascular endothelial growth factor receptor (VEGFR) is one of the well-known targets that
control angiogenesis and cancer progression. In this study, we are reporting the design …

The scientists, and the researchers around the globe generate tremendous amount of
information everyday; for instance, so far more than 74 million molecules are registered in …