Dynamics of single‐cell gene expression
D Longo, J Hasty - Molecular systems biology, 2006 - embopress.org
Cellular behavior has traditionally been investigated by utilizing bulk‐scale methods that
measure average values for a population of cells. Such population‐wide studies mask the …
measure average values for a population of cells. Such population‐wide studies mask the …
Impact of gene expression noise on organismal fitness and the efficacy of natural selection
Z Wang, J Zhang - Proceedings of the National Academy of …, 2011 - National Acad Sciences
Gene expression noise is a universal phenomenon across all life forms. Although beneficial
under certain circumstances, expression noise is generally thought to be deleterious …
under certain circumstances, expression noise is generally thought to be deleterious …
Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish
Reduced parasitic infection rates in the developed world are suspected to underlie the rising
prevalence of autoimmune disorders. However, the long-term evolutionary consequences of …
prevalence of autoimmune disorders. However, the long-term evolutionary consequences of …
Positive selection for elevated gene expression noise in yeast
It is well known that the expression noise is lessened by natural selection for genes that are
important for cell growth or are sensitive to dosage. In theory, expression noise can also be …
important for cell growth or are sensitive to dosage. In theory, expression noise can also be …
Systems biology of robustness and homeostatic mechanisms
HF Nijhout, JA Best, MC Reed - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
All organisms are subject to large amounts of genetic and environmental variation and have
evolved mechanisms that allow them to function well in spite of these challenges. This …
evolved mechanisms that allow them to function well in spite of these challenges. This …
MicroRNA regulation of macrophages in human pathologies
Y Wei, A Schober - Cellular and Molecular Life Sciences, 2016 - Springer
Macrophages play a crucial role in the innate immune system and contribute to a broad
spectrum of pathologies, like in the defence against infectious agents, in inflammation …
spectrum of pathologies, like in the defence against infectious agents, in inflammation …
Tagging mammalian transcription complexity
P Carninci - TRENDS in Genetics, 2006 - cell.com
The nature of the 'transcriptome'is more complex than first realized. Although CAGE, various
tagging technologies and tiling arrays show that most of the mammalian genome is …
tagging technologies and tiling arrays show that most of the mammalian genome is …
Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays
The transcriptome profile of human monocyte-derived macrophages stimulated in vitro by
low doses of IL-1 or IL-6 was analyzed by microarrays (Affymetrix, HG-U133A) in 5 …
low doses of IL-1 or IL-6 was analyzed by microarrays (Affymetrix, HG-U133A) in 5 …
Facile and rapid generation of large-scale microcollagen gel array for long-term single-cell 3D culture and cell proliferation heterogeneity analysis
Z Guan, S Jia, Z Zhu, M Zhang, CJ Yang - Analytical chemistry, 2014 - ACS Publications
Microfabricated devices are suitable for single-cell analysis due to their high throughput,
compatible dimensions and controllable microenvironment. However, existing devices for …
compatible dimensions and controllable microenvironment. However, existing devices for …