The nucleolus is the most prominent nuclear body and serves a fundamentally important
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …

A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

The nucleolus is the largest biomolecular condensate and facilitates transcription,
processing, and assembly of ribosomal RNA (rRNA). Although nucleolar function is thought …

Phase separation of biomolecules into condensates has emerged as a mechanism for
intracellular organization and affects many intracellular processes, including reaction …

In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Controlling interfaces of phase-separating fluid mixtures is key to the creation of diverse
functional soft materials. Traditionally, this is accomplished with surface-modifying chemical …

DNA is organized into chromatin, a complex polymeric material which stores information and
controls gene expression. An emerging mechanism for biological organization, particularly …

The nucleolus is essential for ribosome biogenesis and is involved in many other cellular
functions. We performed a systematic spatiotemporal dissection of the human nucleolar …

Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …

Our understanding of the physical principles organizing the genome in the nucleus is limited
by the lack of tools to directly exert and measure forces on interphase chromosomes in vivo …