Metabolic homeostasis of tissue macrophages across the lifespan
Macrophages are present in almost all organs. Apart from being immune sentinels, tissue-
resident macrophages (TRMs) have organ-specific functions that require a specialized …
resident macrophages (TRMs) have organ-specific functions that require a specialized …
Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls
P Saha, P Ettel, T Weichhart - Trends in Pharmacological Sciences, 2024 - cell.com
Tumor-associated macrophages (TAMs) constitute an important part of the tumor
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …
[HTML][HTML] Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption
J Fan, Y Zhang, M Zuo, S Ding, J Li, S Feng… - Environment …, 2024 - Elsevier
Deoxynivalenol (DON) is a common environmental pollutant that poses a serious health risk
to humans worldwide. This study was aim to explore whether gut microbiota is involved in …
to humans worldwide. This study was aim to explore whether gut microbiota is involved in …
[HTML][HTML] Epithelial metabolism as a rheostat for intestinal inflammation and malignancy
The gut epithelium protects the host from a potentially hostile environment while allowing
nutrient uptake that is vital for the organism. To maintain this delicate task, the gut epithelium …
nutrient uptake that is vital for the organism. To maintain this delicate task, the gut epithelium …
Colonic macrophages eat and feed
J Van den Bossche - Cell metabolism, 2023 - cell.com
Macrophages not only secure host defense via phagocytosis but also play a key role in
tissue homeostasis. A comprehensive study by Fritsch et al. reveals a novel mechanism by …
tissue homeostasis. A comprehensive study by Fritsch et al. reveals a novel mechanism by …
Mucin alleviates colonic barrier dysfunction by promoting spermine accumulation through enhanced arginine metabolism in Limosilactobacillus mucosae
X Zhou, Q Xu, X Zhang, H Wang, Y Bai, Y Wu, X Liu… - Msystems, 2024 - Am Soc Microbiol
Dietary fiber deprivation is linked to probiotic extinction, mucus barrier dysbiosis, and the
overgrowth of mucin-degrading bacteria. However, whether and how mucin could rescue …
overgrowth of mucin-degrading bacteria. However, whether and how mucin could rescue …
Not just sugar: metabolic control of neutrophil development and effector functions
P Ettel, T Weichhart - Journal of Leukocyte Biology, 2024 - academic.oup.com
The mammalian immune system is constantly surveying our tissues to clear pathogens and
maintain tissue homeostasis. In order to fulfill these tasks, immune cells take up nutrients to …
maintain tissue homeostasis. In order to fulfill these tasks, immune cells take up nutrients to …
Mechanism of electro-acupuncture in alleviating intestinal injury in septic mice via polyamine-related M2-macrophage polarization
X Xu, X Huang, L Xiao, J Wang, X Yang… - Frontiers in …, 2024 - frontiersin.org
Objective The objective of this study was to investigate the impact of electro-acupuncture
(EA) on sepsis-related intestinal injury and its relationship with macrophage polarization …
(EA) on sepsis-related intestinal injury and its relationship with macrophage polarization …
Unraveling Evolutionary Dynamics: Insights from In Silico Experiments on Selective Mechanisms in Controlled Environments
M Ledda, A Pluchino, M Ragusa - bioRxiv, 2023 - biorxiv.org
In this paper, we present a series of in silico experiments aimed at probing the evolutionary
properties of our model. Our investigation encompasses multiple methodologies, beginning …
properties of our model. Our investigation encompasses multiple methodologies, beginning …