Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …

Burn trauma produces significant fluid shifts that, in turn, reduce cardiac output and tissue
perfusion. Treatment approaches to major burn injury include administration of crystalloid …

Background—Cardiovascular ischemic events may occur more frequently in hypertensive
patients with activated renin-angiotensin systems. We tested the hypothesis that angiotensin …

We showed before that in cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic
concentrations of ouabain causes hypertrophy and transcriptional regulations of growth …

Growing evidence from patients with heart failure and from experimental animal models
implicates effectors of innate immunity in the pathogenesis of this syndrome. The expression …

Dietary antioxidants may attenuate oxidative damage from strenuous exercise in various
tissues. Beneficial effects of the antioxidant astaxanthin have been demonstrated in vitro, but …

The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-
responsive transcription factors AP-1 and NF-κB, which have been shown to be important for …

Background Chronic kidney disease (CKD) is a significant risk factor for premature
cardiovascular disease and death. Increased oxidative stress in people with CKD has been …

Exposure of neonatal rat cardiac myocytes to ouabain concentrations that caused partial
inhibition of Na+/K+-ATPase but no loss of viability, increased c-fos and c-jun mRNAs and …

NF-κB is a pleiotropic transcription factor implicated in the regulation of diverse biological
phenomena, including apoptosis, cell survival, cell growth, cell division, innate immunity …