Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
Complexity of the alternative splicing landscape in plants
Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …
organisms to increase their coding potential and regulate gene expression through multiple …
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification
MT Parker, K Knop, AV Sherwood, NJ Schurch… - Elife, 2020 - elifesciences.org
Understanding genome organization and gene regulation requires insight into RNA
transcription, processing and modification. We adapted nanopore direct RNA sequencing to …
transcription, processing and modification. We adapted nanopore direct RNA sequencing to …
Global impact of unproductive splicing on human gene expression
Alternative splicing (AS) in human genes is widely viewed as a mechanism for enhancing
proteomic diversity. AS can also impact gene expression levels without increasing protein …
proteomic diversity. AS can also impact gene expression levels without increasing protein …
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome
CY Cheng, V Krishnakumar, AP Chan… - The Plant …, 2017 - Wiley Online Library
The flowering plant Arabidopsis thaliana is a dicot model organism for research in many
aspects of plant biology. A comprehensive annotation of its genome paves the way for …
aspects of plant biology. A comprehensive annotation of its genome paves the way for …
Widespread intron retention in mammals functionally tunes transcriptomes
U Braunschweig, NL Barbosa-Morais, Q Pan… - Genome …, 2014 - genome.cshlp.org
Alternative splicing (AS) of precursor RNAs is responsible for greatly expanding the
regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS …
regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS …
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point
Recurrent mutations in the spliceosome are observed in several human cancers, but their
functional and therapeutic significance remains elusive. SF3B1, the most frequently mutated …
functional and therapeutic significance remains elusive. SF3B1, the most frequently mutated …
Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …
[HTML][HTML] Mechanism of alternative splicing and its regulation
Y Wang, J Liu, BO Huang, YM Xu, J Li… - Biomedical …, 2015 - spandidos-publications.com
Alternative splicing of precursor mRNA is an essential mechanism to increase the
complexity of gene expression, and it plays an important role in cellular differentiation and …
complexity of gene expression, and it plays an important role in cellular differentiation and …
A physical, genetic and functional sequence assembly of the barley genome.
Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important
crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present …
crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present …