Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Low-to-moderate red wine consumption appeared to reduce age-related neurological
disorders including macular degeneration, stroke, and cognitive deficits with or without …

The global popularity of herbal supplements and the promise they hold in treating various
disease states has caused an unprecedented interest in understanding the molecular basis …

Abstract Resveratrol (3, 5, 4′-trihydroxystilbene) extends the lifespan of diverse species
including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila …

In stroke and neurodegenerative disease, neuronal excitotoxicity, caused by increased
extracellular glutamate levels, is known to result in calcium overload and mitochondrial …

A variety of antioxidant compounds derived from natural products (nutraceuticals) have
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …

MicroRNAs are posttranscriptional gene regulators that are differentially expressed during
various diseases and have been implicated in the underlying pathogenesis. We report here …

The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …