The importance of antimicrobial peptides (AMPs) in amphibian skin defense
LA Rollins-Smith - Developmental & Comparative Immunology, 2023 - Elsevier
Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple
bacteria to complex mammalian species. Some amphibian families have developed this …
bacteria to complex mammalian species. Some amphibian families have developed this …
A comprehensive review of patented antimicrobial peptides from amphibian anurans
Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin
secretions have unveiled remarkable structural diversity and a wide range of activities. This …
secretions have unveiled remarkable structural diversity and a wide range of activities. This …
Global Amphibian Declines, Disease, and the Ongoing Battle between Batrachochytrium Fungi and the Immune System
LA Rollins-Smith - Herpetologica, 2020 - meridian.allenpress.com
In the approximately 30 years since the recognition of the crisis of global amphibian
declines, much has been learned about the likely causes. Among the leading causes are …
declines, much has been learned about the likely causes. Among the leading causes are …
Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes
S Aguilar, AE Brunetti, AV Garay, LC Santos, LO Perez… - Peptides, 2023 - Elsevier
Amphibians have a great diversity of bioactive peptides in their skin. The cDNA prepro-
peptide sequencing allowed the identification of five novel mature peptides expressed in the …
peptide sequencing allowed the identification of five novel mature peptides expressed in the …
Molecular basis of a bacterial-amphibian symbiosis revealed by comparative genomics, modeling, and functional testing
The molecular bases for the symbiosis of the amphibian skin microbiome with its host are
poorly understood. Here, we used the odor-producer Pseudomonas sp. MPFS and the …
poorly understood. Here, we used the odor-producer Pseudomonas sp. MPFS and the …
Novel ocellatin peptides mitigate LPS-induced ROS formation and NF-kB activation in microglia and hippocampal neurons
NA Sousa, GAL Oliveira, AP de Oliveira, ALF Lopes… - Scientific Reports, 2020 - nature.com
Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with
potential for biotechnological applications. Therefore, this study aimed to determine the …
potential for biotechnological applications. Therefore, this study aimed to determine the …
Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays
RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …
therefore are attractive sources for new leads in drug discovery. This review describes drug …
The significance of hypervariability and conserved motifs in antimicrobial peptides from tree frogs
AE Brunetti, CA Fuzo, S Aguilar… - Journal of Natural …, 2023 - ACS Publications
Amphibians' skin is a rich source of natural antimicrobial peptides (AMPs). These AMPs
exhibit marked inter-and intraspecific sequence divergence linked to the arms race between …
exhibit marked inter-and intraspecific sequence divergence linked to the arms race between …
Picturins and Pictuseptins, two novel antimicrobial peptide families from the skin secretions of the Chachi treefrog, Boana picturata
G Morán-Marcillo, VS Hinojosa… - Journal of …, 2022 - Elsevier
Abstract The Imbabura treefrog (Boana picturata) is an underexplored source of bioactive
peptides. The combination of molecular cloning and mass spectrometry allowed us to …
peptides. The combination of molecular cloning and mass spectrometry allowed us to …
Use of whole‐body cryosectioning and desorption electrospray ionization mass spectrometry imaging to visualize alkaloid distribution in poison frogs
AM Jeckel, K Matsumura, K Nishikawa… - Journal of Mass …, 2020 - Wiley Online Library
Ambient mass spectrometry is useful for analyzing compounds that would be affected by
other chemical procedures. Poison frogs are known to sequester alkaloids from their diet …
other chemical procedures. Poison frogs are known to sequester alkaloids from their diet …