The importance of antimicrobial peptides (AMPs) in amphibian skin defense

LA Rollins-Smith - Developmental & Comparative Immunology, 2023 - Elsevier
Antimicrobial peptides (AMPs) are produced for defense in nearly all taxa from simple
bacteria to complex mammalian species. Some amphibian families have developed this …

A comprehensive review of patented antimicrobial peptides from amphibian anurans

FA García, TF Fuentes, IP Alonso… - Journal of Natural …, 2024 - ACS Publications
Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin
secretions have unveiled remarkable structural diversity and a wide range of activities. This …

Global Amphibian Declines, Disease, and the Ongoing Battle between Batrachochytrium Fungi and the Immune System

LA Rollins-Smith - Herpetologica, 2020 - meridian.allenpress.com
In the approximately 30 years since the recognition of the crisis of global amphibian
declines, much has been learned about the likely causes. Among the leading causes are …

Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes

S Aguilar, AE Brunetti, AV Garay, LC Santos, LO Perez… - Peptides, 2023 - Elsevier
Amphibians have a great diversity of bioactive peptides in their skin. The cDNA prepro-
peptide sequencing allowed the identification of five novel mature peptides expressed in the …

Molecular basis of a bacterial-amphibian symbiosis revealed by comparative genomics, modeling, and functional testing

AE Brunetti, B Bunk, ML Lyra, CA Fuzo… - The ISME …, 2022 - academic.oup.com
The molecular bases for the symbiosis of the amphibian skin microbiome with its host are
poorly understood. Here, we used the odor-producer Pseudomonas sp. MPFS and the …

Novel ocellatin peptides mitigate LPS-induced ROS formation and NF-kB activation in microglia and hippocampal neurons

NA Sousa, GAL Oliveira, AP de Oliveira, ALF Lopes… - Scientific Reports, 2020 - nature.com
Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with
potential for biotechnological applications. Therefore, this study aimed to determine the …

Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays

RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …

The significance of hypervariability and conserved motifs in antimicrobial peptides from tree frogs

AE Brunetti, CA Fuzo, S Aguilar… - Journal of Natural …, 2023 - ACS Publications
Amphibians' skin is a rich source of natural antimicrobial peptides (AMPs). These AMPs
exhibit marked inter-and intraspecific sequence divergence linked to the arms race between …

Picturins and Pictuseptins, two novel antimicrobial peptide families from the skin secretions of the Chachi treefrog, Boana picturata

G Morán-Marcillo, VS Hinojosa… - Journal of …, 2022 - Elsevier
Abstract The Imbabura treefrog (Boana picturata) is an underexplored source of bioactive
peptides. The combination of molecular cloning and mass spectrometry allowed us to …

Use of whole‐body cryosectioning and desorption electrospray ionization mass spectrometry imaging to visualize alkaloid distribution in poison frogs

AM Jeckel, K Matsumura, K Nishikawa… - Journal of Mass …, 2020 - Wiley Online Library
Ambient mass spectrometry is useful for analyzing compounds that would be affected by
other chemical procedures. Poison frogs are known to sequester alkaloids from their diet …