TGFβ biology in cancer progression and immunotherapy

R Derynck, SJ Turley, RJ Akhurst - Nature Reviews Clinical Oncology, 2021 - nature.com
TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Targeting TGFβ signal transduction for cancer therapy

S Liu, J Ren, P Ten Dijke - Signal transduction and targeted therapy, 2021 - nature.com
Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …

The Synergistic Cooperation between TGF-β and hypoxia in Cancer and fibrosis

P Mallikarjuna, Y Zhou, M Landström - Biomolecules, 2022 - mdpi.com
Transforming growth factor β (TGF-β) is a multifunctional cytokine regulating homeostasis
and immune responses in adult animals and humans. Aberrant and overactive TGF-β …

Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop

K Lei, X Liang, Y Gao, B Xu, Y Xu, Y Li, Y Tao… - Biochemical and …, 2017 - Elsevier
The long noncoding RNA (lncRNA) ATB is an important regulator in human tumors. Here,
we aimed to investigate the potential molecular mechanisms of lnc-ATB in gastric cancer …

[HTML][HTML] Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer

RL Lin, LJ Zhao - Cancer biology & medicine, 2015 - ncbi.nlm.nih.gov
Transforming growth factor-β (TGF-β) is a key factor in cancer development and progression.
TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating …

SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C

D Liu, L Li, XX Zhang, DY Wan, BX Xi, Z Hu, WC Ding… - Cancer research, 2014 - AACR
Lymphatic vessels are one of the major routes for the dissemination of cancer cells.
Malignant tumors release growth factors such as VEGF-C to induce lymphangiogenesis …

[HTML][HTML] Hot and cold tumors: is endoglin (CD105) a potential target for vessel normalization?

C Ollauri-Ibáñez, B Ayuso-Íñigo, M Pericacho - Cancers, 2021 - mdpi.com
Tumors are complex masses formed by malignant but also by normal cells. The interaction
between these cells via cytokines, chemokines, growth factors, and enzymes that remodel …

The role of endoglin in post-ischemic revascularization

E Núñez-Gómez, M Pericacho, C Ollauri-Ibáñez… - Angiogenesis, 2017 - Springer
Following arterial occlusion, blood vessels respond by forming a new network of functional
capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of …

Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies

C Ollauri-Ibanez, JM Lopez-Novoa… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Alterations in the process of angiogenesis, either by excess or by defect, are
present in different common pathologies. For this reason, great efforts are being made …

Endoglin for tumor imaging and targeted cancer therapy

M Paauwe, P Ten Dijke… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Although cancer treatment has evolved substantially in the past decades,
cancer-related mortality rates are still increasing. Therapies targeting tumor angiogenesis …