Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

Several lines of evidence from neuropathological studies, human genetics, in vitro
aggregation studies and cellular and animal models support the hypothesis that aSyn plays …

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …

Synucleinopathies are a group of disorders characterized by the accumulation of inclusions
rich in the a‐synuclein (aSyn) protein. This group of disorders includes Parkinson's disease …

Lewy Body Disorders (LBDs) lie within the spectrum of age-related neurodegenerative
diseases now frequently categorized as the synucleinopathies. LBDs are considered to be …

The intracellular misfolding and accumulation of alpha-synuclein into structures collectively
called Lewy pathology (LP) is a central phenomenon for the pathogenesis of …

Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10)
gene have been associated with autosomal-dominant Parkinson's disease (PD), PD …

The aggregation of intrinsically disordered proteins is a hallmark of neurodegenerative
diseases, such as Alzheimer's, Parkinson's and Huntington's disease. Although we currently …

Transcription factor EB is a master regulator of genes involved in the maintenance of
autophagic and lysosomal homeostasis, processes which have been implicated in the …

Abstract Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson's
disease and other progressive neurodegenerative disorders known as Lewy body diseases …