Remarkably flexible quinazolinones—synthesis and biological applications
MM Reddy, A Sivaramakrishna - Journal of Heterocyclic …, 2020 - Wiley Online Library
Even though several quinazolinone derivatives have been synthesized, still there is a
constant demand for designing and synthesis of new quinazolinone derivatives by fine …
constant demand for designing and synthesis of new quinazolinone derivatives by fine …
Hybrids of coumarin derivatives as potent and multifunctional bioactive agents: A review
I Fotopoulos, D Hadjipavlou-Litina - Medicinal Chemistry, 2020 - ingentaconnect.com
Background: Coumarins exhibit a plethora of biological activities, eg antiinflammatory and
anti-tumor. Molecular hybridization technique has been implemented in the design of novel …
anti-tumor. Molecular hybridization technique has been implemented in the design of novel …
[HTML][HTML] Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury
L Song, G Li, W Guan, Z Zeng, Y Ou, T Zhao, J Li… - Biomedicine & …, 2023 - Elsevier
Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality
rate. Medications with anti-inflammatory small molecules have been demonstrated in phase …
rate. Medications with anti-inflammatory small molecules have been demonstrated in phase …
Metabolic syndrome ameliorated by 4-methylesculetin by reducing hepatic lipid accumulation
L Li, G Zhu, G Fu, W Zha, H Li - International Journal of Molecular …, 2022 - mdpi.com
Obesity is a chronic metabolic disease caused by an imbalance between energy intake and
expenditure during a long period and is characterized by adipose tissue disfunction and …
expenditure during a long period and is characterized by adipose tissue disfunction and …
Cichoriin, a biocoumarin, mitigates oxidative stress and associated adverse dysfunctions on high-fat diet-induced obesity in rats
Metabolic dysfunctions linked to obesity carry the risk of co-morbidities such as diabetes,
hepatorenal, and cardiovascular diseases. Coumarins are believed to display several …
hepatorenal, and cardiovascular diseases. Coumarins are believed to display several …
3-Phenylcoumarins as a privileged scaffold in Medicinal Chemistry: The landmarks of the past decade
3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both
organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is …
organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is …
Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist
A Abdul-Ridha, LA de Zhang, AH Betrie… - ACS Chemical …, 2024 - ACS Publications
α1A-, α1B-, and α1D-adrenoceptors (α1-ARs) are members of the adrenoceptor G protein-
coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline …
coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline …
New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome
T Monteiro-Alfredo, MLR Macedo… - International Journal of …, 2023 - mdpi.com
Brazil has several important biomes holding impressive fauna and flora biodiversity.
Cerrado being one of the richest ones and a significant area in the search for new plant …
Cerrado being one of the richest ones and a significant area in the search for new plant …
Novel tetrahydroquinazolinamines as selective histamine 3 receptor antagonists for the treatment of obesity
The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several
neurotransmitters including histamine and various essential physiological processes, such …
neurotransmitters including histamine and various essential physiological processes, such …
Utility of ZrO2–Al2O3 in the synthesis of 2, 3-dihydroquinazolin-4 (1H)-ones
In this paper, we report the synthesis of a nano acid catalyst ZrO 2–Al 2 O 3 by using urea as
a fuel and the evaluation of its catalytic efficiency in the synthesis of a series of novel …
a fuel and the evaluation of its catalytic efficiency in the synthesis of a series of novel …