Even though several quinazolinone derivatives have been synthesized, still there is a
constant demand for designing and synthesis of new quinazolinone derivatives by fine …

Background: Coumarins exhibit a plethora of biological activities, eg antiinflammatory and
anti-tumor. Molecular hybridization technique has been implemented in the design of novel …

Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality
rate. Medications with anti-inflammatory small molecules have been demonstrated in phase …

Obesity is a chronic metabolic disease caused by an imbalance between energy intake and
expenditure during a long period and is characterized by adipose tissue disfunction and …

Metabolic dysfunctions linked to obesity carry the risk of co-morbidities such as diabetes,
hepatorenal, and cardiovascular diseases. Coumarins are believed to display several …

3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both
organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is …

α1A-, α1B-, and α1D-adrenoceptors (α1-ARs) are members of the adrenoceptor G protein-
coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline …

Brazil has several important biomes holding impressive fauna and flora biodiversity.
Cerrado being one of the richest ones and a significant area in the search for new plant …

The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several
neurotransmitters including histamine and various essential physiological processes, such …

In this paper, we report the synthesis of a nano acid catalyst ZrO 2–Al 2 O 3 by using urea as
a fuel and the evaluation of its catalytic efficiency in the synthesis of a series of novel …