[HTML][HTML] The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Mechanism of interaction between autophagy and apoptosis in cancer

S Das, N Shukla, SS Singh, S Kushwaha… - Apoptosis, 2021 - Springer
The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Mechanism of ferroptosis and its role in type 2 diabetes mellitus

W Sha, F Hu, Y Xi, Y Chu, S Bu - Journal of diabetes research, 2021 - Wiley Online Library
Ferroptosis is a novel form of nonapoptotic regulated cell death (RCD). It features iron‐
dependent lipid peroxide accumulation accompanied by inadequate redox enzymes …

Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues

S Kumari, R Dhapola, DHK Reddy - Apoptosis, 2023 - Springer
Alzheimer's disease (AD) is characterized by the accumulation of hyperphosphorylated tau
and amyloid-β (Aβ) protein resulting in synaptic loss and apoptosis. Aβ and tau deposition …

[HTML][HTML] Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression

J Ježek, KF Cooper, R Strich - Antioxidants, 2018 - mdpi.com
Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

DRP1 interacts directly with BAX to induce its activation and apoptosis

A Jenner, A Peña‐Blanco, R Salvador‐Gallego… - The EMBO …, 2022 - embopress.org
The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …

[HTML][HTML] A cell's fate: an overview of the molecular biology and genetics of apoptosis

GC Cavalcante, AP Schaan, GF Cabral… - International journal of …, 2019 - mdpi.com
Apoptosis is one of the main types of regulated cell death, a complex process that can be
triggered by external or internal stimuli, which activate the extrinsic or the intrinsic pathway …

Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases

M Tang, Z Chen, D Wu, L Chen - Journal of cellular physiology, 2018 - Wiley Online Library
Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that
specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in …

Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

[HTML][HTML] Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …