mTOR at the nexus of nutrition, growth, ageing and disease
GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
Metabolic regulation of cell growth and proliferation
J Zhu, CB Thompson - Nature reviews Molecular cell biology, 2019 - nature.com
Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …
that support cellular bioenergetics and survival have been well studied. By contrast, how …
mTOR as a central hub of nutrient signalling and cell growth
J Kim, KL Guan - Nature cell biology, 2019 - nature.com
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …
known as mammalian target of rapamycin) is a central cell growth regulator connecting …
mTOR signalling and cellular metabolism are mutual determinants in cancer
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer
Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …
Targeting the biology of aging with mTOR inhibitors
JB Mannick, DW Lamming - Nature Aging, 2023 - nature.com
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
G Napolitano, C Di Malta, A Esposito, MEG de Araujo… - Nature, 2020 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that
controls the cellular response to environmental cues by exerting its kinase activity on …
controls the cellular response to environmental cues by exerting its kinase activity on …
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini - Cell, 2017 - cell.com
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …
metabolism with environmental inputs, including nutrients and growth factors. Extensive …
The role of mTOR signaling as a therapeutic target in cancer
NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …