mTOR at the nexus of nutrition, growth, ageing and disease

GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control

A González, MN Hall, SC Lin, DG Hardie - Cell metabolism, 2020 - cell.com
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Metabolic regulation of cell growth and proliferation

J Zhu, CB Thompson - Nature reviews Molecular cell biology, 2019 - nature.com
Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

mTOR as a central hub of nutrient signalling and cell growth

J Kim, KL Guan - Nature cell biology, 2019 - nature.com
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …

mTOR signalling and cellular metabolism are mutual determinants in cancer

D Mossmann, S Park, MN Hall - Nature Reviews Cancer, 2018 - nature.com
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer

S Patergnani, A Danese, E Bouhamida… - International journal of …, 2020 - mdpi.com
Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Targeting the biology of aging with mTOR inhibitors

JB Mannick, DW Lamming - Nature Aging, 2023 - nature.com
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

G Napolitano, C Di Malta, A Esposito, MEG de Araujo… - Nature, 2020 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that
controls the cellular response to environmental cues by exerting its kinase activity on …

mTOR signaling in growth, metabolism, and disease

RA Saxton, DM Sabatini - Cell, 2017 - cell.com
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

The role of mTOR signaling as a therapeutic target in cancer

NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …