Abnormal regulation of gene expression is essential for tumorigenesis. Several studies
indicate that regulation of oncogene expression and neoplastic transformation are controlled …

Abstract eIF3a is the largest subunit of eIF3, which is a key player in all steps of translation
initiation. During the past years, eIF3a is recognized as a proto-oncogene, which is an …

Drug resistance is a major problem in cancer treatment with traditional or targeted
therapeutics. Gemcitabine is approved for several human cancers and the first line treatment …

Our previous studied indicated that eukaryotic translation initiation factor 3a (eIF3a)
increases the sensitive of platinum-based chemotherapy in lung cancer. MiRNAs play an …

Cancer stem cells (CSCs) are the leading cause of recurrence and poor prognosis in non-
small cell lung cancer (NSCLC). Eukaryotic translation initiation factor 3a (eIF3a) …

Translational control is an essential process in regulation of gene expression, which occurs
at the initiation step performed by a number of translation initiation factor complexes. eIF3a …

Purpose: The purpose of this study is to test the hypothesis that eIF3a may regulate the
expression of DNA repair proteins which, in turn, affects response of lung cancer patients to …

Although the roles of Jak-Stat pathways in type I and II interferon (IFN)-dependent
transcriptional regulation are well established, the precise mechanisms of mRNA translation …

Background Laryngeal squamous cell carcinoma (LSCC) is the most common type in head
and neck squamous cell carcinoma (HNSCC), and the development and progression of …

Colorectal cancer (CRC) is the third most common cause of cancer related death worldwide.
Furthermore, with more than 1.2 million cases registered per year, it constitutes the third …