Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …

High-order chromatin structure plays important roles in gene expression regulation.
Knowledge of the dynamics of 3D chromatin structures during mammalian embryo …

Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …

The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

The mammalian sperm genome is thought to lack substantial information for the regulation
of future expression after fertilization. Here, we show that most promoters in mouse sperm …

More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

The mechanisms by which environmentally-induced epiphenotypes are transmitted
transgenerationally in mammals are poorly understood. Here we show that exposure of …

Active DNA demethylation in mammals involves ten-eleven translocation (TET) family
protein-mediated oxidation of 5-methylcytosine (5mC). However, base-resolution …