As non-intrusive polynomial chaos expansion (PCE) techniques have gained growing
popularity among researchers, we here provide a comprehensive review of major sampling …

Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics …

Irrespective of whether a drug is in development or already available on the market, the
current paradigm for paediatric dose selection does not guarantee safe and effective dosing …

Morphine is a widely used opioid for treatment of moderate to severe pain, but large
interindividual variability in patient response and no clear guidance on how to optimise …

In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

These two items now work properly in nm751. 2) For problems using analytical 2nd
derivatives (such as $ EST LAPLACE NOINTERACTION without NUMERICAL, or $ SIM …

Several developments have facilitated the practical application and increased the general
use of optimal design for nonlinear mixed effects models. These developments include new …

Background Sepsis and bacterial meningitis are major causes of mortality and morbidity in
neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in …

Population pharmacokinetic (PK)–pharmacodynamic (PKPD) models are increasingly used
in drug development and in academic research; hence, designing efficient studies is an …