Cisplatin in ovarian cancer treatment—known limitations in therapy force new solutions

A Zoń, I Bednarek - International journal of molecular sciences, 2023 - mdpi.com
Cisplatin is one of the most commonly used anticancer drugs worldwide. It is mainly used in
the treatment of ovarian cancer, but also used in testicular, bladder and lung cancers. The …

The gold complex auranofin: new perspectives for cancer therapy

FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

Antioxidant supplementation in the treatment of neurotoxicity induced by platinum-based chemotherapeutics—a review

JSK Stankovic, D Selakovic, V Mihailovic… - International Journal of …, 2020 - mdpi.com
Cancer represents one of the most pernicious public health problems with a high mortality
rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches …

Revisiting the anti-cancer toxicity of clinically approved platinating derivatives

BN Forgie, R Prakash, CM Telleria - International Journal of Molecular …, 2022 - mdpi.com
Cisplatin (CDDP), carboplatin (CP), and oxaliplatin (OXP) are three platinating agents
clinically approved worldwide for use against a variety of cancers. They are canonically …

Non-coding RNA-mediated autophagy in cancer: A protumor or antitumor factor?

J Liang, L Zhang, W Cheng - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
Autophagy, usually referred to as macroautophagy, is a cytoprotective behavior that helps
cells, especially cancer cells, escape crises. However, the role of autophagy in cancer …

Four types of RNA modification writer-related lncRNAs are effective predictors of prognosis and immunotherapy response in serous ovarian carcinoma

L Ye, K Pan, S Fang, SN Wu, S Chen, S Tang… - Frontiers in …, 2022 - frontiersin.org
Serous ovarian carcinoma (SOC) is a gynecological malignancy with high mortality rates.
Currently, there is a lack of reliable biomarkers for accurate SOC patient prognosis. Here, we …

Blockade LAT1 mediates methionine metabolism to overcome oxaliplatin resistance under hypoxia in renal cell carcinoma

Q Xu, Y Liu, W Sun, T Song, X Jiang, K Zeng, S Zeng… - Cancers, 2022 - mdpi.com
Simple Summary The transformation and mechanism of methionine metabolism of renal cell
carcinoma (RCC) under a hypoxic microenvironment is not well understood as yet. This …

[HTML][HTML] Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS

D Li, Y Kou, Y Gao, S Liu, P Yang, T Hasegawa… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors
worldwide, and its prognosis is still not optimistic. Oxaliplatin is a type of platinum …

Enhancer of zeste homolog 2 promotes cisplatin resistance by reducing cellular platinum accumulation

S Sun, S Zhao, Q Yang, W Wang, E Cai, Y Wen… - Cancer …, 2018 - Wiley Online Library
Enhancer of zeste homolog 2 (EZH2), which is overexpressed in a wide range of tumors,
contributes to ovarian cancer malignancy in several different ways. We aimed to illustrate the …

PTOV1 promotes cisplatin-induced chemotherapy resistance by activating the nuclear factor kappa B pathway in ovarian cancer

H Shen, B Liao, Z Wan, Y Zhao, Z You, J Liu… - Molecular Therapy …, 2021 - cell.com
Chemotherapy resistance is a bottleneck for ovarian cancer treatment; therefore, revealing
its regulatory mechanism is critical. In the present study, we found that prostate tumor …