Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions.
There is no cure for most of these diseases, and the treatment relies on drugs that have side …

Snakebite envenoming is the cause of an ongoing health crisis in several regions of the
world, particularly in tropical and neotropical countries. This scenario creates an urgent …

Background The treatment for snakebites is early administration of antivenom, which can be
highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the …

Myotoxin-II, a phospholipase A 2 (PLA 2)-like protein found in Bothrops asper venom,
causes rapid necrosis of muscle fibers in spite of lacking enzymatic activity. This toxic action …

Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the
sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a …

Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A 2 (PLA 2)
originally developed to control inflammatory cascades of diseases associated with high or …

The presence of the G-quadruplex (G4) structure in the promoter region of the human bcl-2
oncogenes makes it a promising target for developing anti-cancer therapeutics. Bcl-2 …

Viper venom phospholipase A2 enzymes (vvPLA2s) and phospholipase A2-like (PLA2-like)
proteins are two of the principal toxins in viper venom that are responsible for the severe …

Snakebite is a significant health concern in tropical and subtropical regions, particularly in
Africa, Asia, and Latin America, resulting in more than 2.7 million envenomations and an …