Advances in organ-on-a-chip engineering
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
Advances in Spheroids and Organoids on a Chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
F Bonanini, D Kurek, S Previdi, A Nicolas, D Hendriks… - Angiogenesis, 2022 - Springer
With recent progress in modeling liver organogenesis and regeneration, the lack of
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …
Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …
progressing from academic proof-of-concept studies to valid solutions to real-world …
Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues
The vasculature is an essential component of the circulatory system that plays a vital role in
the development, homeostasis, and disease of various organs in the human body. The …
the development, homeostasis, and disease of various organs in the human body. The …
A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature
Owing to their high spatiotemporal precision and adaptability to different host cells, organ-on-
a-chip systems are showing great promise in drug discovery, developmental biology studies …
a-chip systems are showing great promise in drug discovery, developmental biology studies …
Recent advances in multicellular tumor spheroid generation for drug screening
KH Lee, TH Kim - Biosensors, 2021 - mdpi.com
Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …
A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases
Development of organoids and microfluidic on-chip models has enabled studies of organ-
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Vascularized tumor spheroid-on-a-chip model verifies synergistic vasoprotective and chemotherapeutic effects
Prolyl hydroxylases (PHD) inhibitors have been observed to improve drug distribution in
mice tumors via blood vessel normalization, increasing the effectiveness of chemotherapy …
mice tumors via blood vessel normalization, increasing the effectiveness of chemotherapy …