Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Stromal fibroblasts become altered in response to solid cancers, to exhibit myofibroblastic
characteristics, with disease promoting influence. Infiltrating mesenchymal stem cells (MSC) …

Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as
mRNAs and microRNAs (miRNAs), between different cells. Mesenchymal stem cells (MSCs) …

Background: A systemic immune-inflammation index (SII) based on neutrophil (N),
lymphocyte (L), and platelet (P) counts has shown a prognostic impact in several solid …

The strategy of using mesenchymal stem cells (MSCs) as a living carrier for active delivery of
therapeutic agents targeting tumor sites has been attempted in a wide range of studies to …

The signal transducer and activator of transcription (STAT) 3 governs essential functions of
epithelial and hematopoietic cells that are often dysregulated in cancer. While the role for …

Metastatic disease is the major challenge of cancer that accounts for over 90% of total
cancer lethality. Mounting clinical and preclinical data now indicate that inflammation, a …

Tumours are complex systems with dynamic interactions between tumour cells, non-tumour
cells, and extracellular components that comprise the tumour microenvironment (TME). The …