The current prevention efforts for STIs, HIV and viral hepatitis in the WHO European Region,
especially in the Central and Eastern subregions, are hindered by healthcare disparities …

Syphilis was perceived to be a new disease in Europe in the late 15th century, igniting a
debate about its origin that continues today in anthropological, historical, and medical …

In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp.
pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in …

The performance of commonly used assays for diagnosis of syphilis varies considerably
depending on stage of infection and sample type. In response to the need for improved …

Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp.
pallidum, has an estimated 6.3 million cases worldwide per annum. In the past ten years, the …

The incidence of syphilis has risen worldwide in the last decade in spite of being an easily
treated infection. The causative agent of this sexually transmitted disease is the bacterium …

Despite more than a century of research, genetic manipulation of Treponema pallidum
subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The …

The recent development of a system for long-term in vitro culture of the syphilis spirochete,
Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic …

The quest for a syphilis vaccine to provide protection from infection or disease began not
long after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) …

Background The incidence of syphilis has increased markedly in the past decade in high-
income countries, including Australia. To date, however, genomic studies of Treponema …