Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

A mosquito needs to ingest at least one male and one female gametocyte to become
infected with malaria. The sex of Plasmodium falciparum gametocytes can be determined …

Drug resistance compromises control of malaria. Here, we show that resistance to a
commonly used antimalarial medication, atovaquone, is apparently unable to spread …

Background DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate
dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We investigated the …

Malaria transmission to mosquitoes requires a developmental switch in asexually dividing
blood-stage parasites to sexual reproduction. In Plasmodium berghei, the transcription factor …

BACKGROUND. Drugs and vaccines that can interrupt the transmission of Plasmodium
falciparum will be important for malaria control and elimination. However, models for early …

Background Single low doses of primaquine, when added to artemisinin-based combination
therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. We …

Background The transmission of malaria to mosquitoes depends on the presence of
gametocytes that circulate in the peripheral blood of infected human hosts. Sensitive …

Background Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity
before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex …

The rapid clearance of malaria parasite DNA from circulation has widely been accepted as a
fact without being systemically investigated. We assessed the persistence of parasite DNA in …