The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents

E Ghobadi, M Moloudizargari, MH Asghari… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Cyclophosphamide (CP) is an alkylating antineoplastic agent with known
toxicity to the male reproductive system. Areas covered: This review summarizes the known …

Immunomodulating tellurium compounds as anti-cancer agents

B Sredni - Seminars in cancer biology, 2012 - Elsevier
Tellurium is a rare element, which has been regarded as a toxic, non-essential trace
element; its biological role, if any, has not been clearly established to date. The investigation …

Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model

R Fusco, AT Salinaro, R Siracusa, R D'Amico… - Antioxidants, 2021 - mdpi.com
Background: Every year, men use cyclophosphamide to treat various cancers and
autoimmune diseases. On the one hand, this chemotherapy often has the beneficial effect of …

PM2. 5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse

L Zhou, X Su, B Li, C Chu, H Sun, N Zhang… - Ecotoxicology and …, 2019 - Elsevier
Exposure to ambient fine particular matter (PM2. 5) has been clearly associated with male
reproductive disorders. However, very limited toxicological studies were carried out to …

Classification of mouse sperm motility patterns using an automated multiclass support vector machines model

SG Goodson, Z Zhang, JK Tsuruta, W Wang… - Biology of …, 2011 - academic.oup.com
Vigorous sperm motility, including the transition from progressive to hyperactivated motility
that occurs in the female reproductive tract, is required for normal fertilization in mammals …

Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells

DN Tripathi, GB Jena - Toxicology, 2008 - Elsevier
Cyclophosphamide (CP), an alkylating agent used in the treatment of several cancers as
well as an immunosuppressant in rheumatoid arthritis. It is used against several cancers due …

Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant‐antioxidant balance, and protective roles of lycopene and ellagic acid

AO Çeribaşi, G Türk, M Sönmez… - Basic & Clinical …, 2010 - Wiley Online Library
In this study, the toxic effect of cyclophosphamide (CP) on sperm morphology, testicular
histology and blood oxidant–antioxidant balance, and protective roles of lycopene (LC) and …

Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis

G Türk, AO Çeribaşi, F Sakin, M Sönmez… - Reproduction, fertility …, 2010 - CSIRO Publishing
The present study was conducted to investigate the possible protective effects of lycopene
(LC) and ellagic acid (EA) on cyclophosphamide (CP)-induced testicular and spermatozoal …

Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation

SG Goodson, Y Qiu, KA Sutton, G Xie… - Biology of …, 2012 - academic.oup.com
Although substantial evidence exists that sperm ATP production via glycolysis is required for
mammalian sperm function and male fertility, conflicting reports involving multiple species …

Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats

AM Abd El Tawab, NN Shahin… - Chemico-Biological …, 2014 - Elsevier
The present study investigated the protective effect of Satureja montana extract against
cyclophosphamide-induced testicular injury in rats. Total phenolic and flavonoid contents of …