Immobilization of l-Asparaginase on Carrier Materials: A Comprehensive Review

A Ulu, B Ates - Bioconjugate chemistry, 2017 - ACS Publications
There are two major applications of l-asparaginase (L-ASNase): leukemia therapy and the
food industry. Especially, its chemotherapeutic effect has attracted interest from the scientific …

Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood …

TA Costa-Silva, IM Costa, HP Biasoto, GM Lima… - Blood Reviews, 2020 - Elsevier
L-asparaginase is an enzyme used as a biopharmaceutical to treat acute lymphoblastic
leukemia. Several adverse effects have been related to L-asparaginase use, so the scientific …

Immobilization of L-asparaginase on magnetic nanoparticles for cancer treatment

H Orhan, D Aktaş Uygun - Applied biochemistry and biotechnology, 2020 - Springer
In this presented work, magnetic poly (HEMA-GMA) nanoparticles were synthesized,
characterized, and used for immobilization of an anti-leukemic enzyme L-asparaginase. The …

[HTML][HTML] l-asparaginase immobilized p (HEMA-GMA) cryogels: A recent study for biochemical, thermodynamic and kinetic parameters

SAA Noma, Ö Acet, A Ulu, B Önal, M Odabaşı, B Ateş - Polymer Testing, 2021 - Elsevier
Cryogels have recently been attracted intense attention as suitable carriers for enzyme
immobilization. Herein, l-asparaginase was selected as the model enzyme due to its …

Expression and characterization of recombinant l-asparaginase from Pseudomonas fluorescens

R Sindhu, HK Manonmani - Protein expression and purification, 2018 - Elsevier
Abstract l-asparaginase (EC 3.5. 1.1), an anti-cancer drug has been used in the treatment of
acute lymphoblastic leukemia. A novel source of l-asparaginase from Pseudomonas …

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

MA Ismail, RK Arafa, MM Youssef… - Drug Design …, 2014 - Taylor & Francis
A series of 15 monocationic bithiophenes and isosteres were prepared and subjected to in
vitro antiproliferative screening using the full National Cancer Institute (NCI)-60 cell line …

Cloning and expression of l-asparaginase from E. coli in eukaryotic expression system

S Sajitha, J Vidya, P Binod, A Pandey - Biochemical engineering journal, 2015 - Elsevier
Abstract l-Asparaginase is an anti-cancer agent which prevents the proliferation of
cancerous cells by decreasing the level of asparagine in the blood. l-asparaginase from …

Synthesis and characterization of PMMA composites activated with starch for immobilization of L‐asparaginase

A Ulu, S Koytepe, B Ates - Journal of Applied Polymer Science, 2016 - Wiley Online Library
ABSTRACT Poly (methyl methacrylate)(PMMA)–starch composites were prepared by
emulsion polymerization technique for L‐asparaginase (L‐ASNase) immobilization as …

Biochemical Characterization of $\small {L} $-Asparaginase in NaCl-Tolerant Staphylococcus sp. OJ82 Isolated from Fermented Seafood

S Han, J Jung, W Park - Journal of Microbiology and Biotechnology, 2014 - koreascience.kr
Abstract $\small {L} $-Asparaginase from gram-positive bacteria has been poorly explored.
We conducted recombinant overexpression and purification of $\small {L} $-asparaginase …

[HTML][HTML] Anticancer activity of extremely effective recombinant L-asparaginase from Burkholderia pseudomallei

DB Darwesh, YS Al-Awthan, I Elfaki… - … of Microbiology and …, 2022 - ncbi.nlm.nih.gov
Abstract L-asparaginase (EC 3.5. 1.1) purified from bacterial cells is widely used in the food
industry, as well as in the treatment of childhood acute lymphoblastic leukemia. In the …