Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological
aspects are still being investigated. Recently, it has been hypothesized that AD may be …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Brain network dysfunction is increasingly recognised in Alzheimer's disease (AD). However,
the causes of brain connectivity disruption are still poorly understood. Recently …

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …