Current evidence suggests that severity and mortality of COVID-19 is higher in men than in
women, whereas women might be at increased risk of COVID-19 reinfection and …

Biological sex is a fundamental source of phenotypic variability across species. Males and
females have different nutritional needs and exhibit differences in nutrient digestion and …

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state …

There are marked sex differences in the prevalence, phenotypic presentation and treatment
response for major depression. While genome-wide association studies (GWAS) adjust for …

There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …

Obesity and upper-body fat distribution are independent, cardiometabolic risk factors but
whether they also display comparable associations with cancer risk is unknown. We …

International differences in the incidence of many cancer types indicate the existence of
carcinogen exposures that have not yet been identified by conventional epidemiology make …

Background Endometrial cancer is the most common gynaecological cancer in high-income
countries. Elevated body mass index (BMI) is an established modifiable risk factor for this …

OBJECTIVE To investigate the causal association of type 2 diabetes and its components
with risk of vascular complications independent of shared risk factors obesity and …

Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to
reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been …