Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …

The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …

When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

It has become apparent that the intestinal microbiota orchestrates important aspects of our
metabolism, immunity, and development. Recent work has demonstrated that the microbiota …

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-
like transmission of protein aggregation. Factors responsible for the initiation of AS …

The intestinal microbiome, the largest reservoir of microorganisms in the human body, plays
an important role in neurological development and aging as well as in brain disorders such …

Two decades have passed since the initial proposition that amyloids are not only (toxic)
byproducts of an unintended aggregation cascade, but that they can also be produced by an …