Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-
based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors …

Metabolic syndrome and its associated disorders such as obesity, insulin resistance,
atherosclerosis and type 2 diabetes mellitus are globally prevalent. Different molecules …

Mitochondria are key organelles for the maintenance of myocardial tissue homeostasis,
playing a pivotal role in adenosine triphosphate (ATP) production, calcium signaling, redox …

Heart failure (HF) is a complex and multifactorial disease that affects millions of people
worldwide. It is characterized by metabolic disturbances of substrates such as glucose, fatty …

Cardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac
function. HDAC3 commonly functions as corepressor by removing acetyl moieties from …

Cardiac lipotoxicity plays an important role in the pathogenesis of obesity-related
cardiovascular disease. The flavonoid quercetin (QUE), a nutraceutical compound that is …

Heart failure (HF) is a leading cause of mortality worldwide. The pathogenesis of HF is
complex and has not yet been fully elucidated, which has slowed drug development and …

Abstract Introduction Angiotensin Converting Enzyme or ACE is an exo-peptidase that
causes the conversion of angiotensin I to angiotensin II, vasoconstriction, and aldosterone …