Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and …
A group of theobromine derivatives was designed based on the key pharmacophoric
characteristics of VEGFR-2 inhibitors. HepG2 and MCF-7 cancer cell lines were used to test …
characteristics of VEGFR-2 inhibitors. HepG2 and MCF-7 cancer cell lines were used to test …
Novel Aminopyrimidine-2, 4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and …
S El-Kalyoubi, SA El-Sebaey, SM Elfeky… - Pharmaceuticals, 2023 - mdpi.com
Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
Design, synthesis, antimicrobial evaluation, and molecular modeling of new sulfamethoxazole and trimethoprim analogs as potential DHPS/DHFR inhibitors
Trimethoprim (TMP) and sulfonamides and are typically utilized to hinder the activities of
dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes …
dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes …
Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade
ME Adly, NA Edris, HH Kadry… - Egyptian Journal of …, 2024 - journals.ekb.eg
The structural diversity and biological significance of pyrimidine core attracted the attention
of many researchers and scientists in the past years owing to their inclusion in the …
of many researchers and scientists in the past years owing to their inclusion in the …
Ambient Temperature Metal‐Free Thiomethylation of Chloroheteroarenes and Chloropurines
MA Patel, RK Vora, YS Sanghvi… - Chemistry–An Asian …, 2024 - Wiley Online Library
Herein, we report an in‐situ mild and metal‐free protocol for thiomethylation of heteroarenes
in high yields. The thiomethylation of various chloropurines, nucleosides, and …
in high yields. The thiomethylation of various chloropurines, nucleosides, and …
Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo …
WB El Gazzar, H Bayoumi, HS Youssef, TA Ibrahim… - Toxics, 2024 - mdpi.com
Imidacloprid (IMI) is a commonly used new-generation pesticide that has numerous harmful
effects on non-targeted organisms, including animals. This study analysed both the adverse …
effects on non-targeted organisms, including animals. This study analysed both the adverse …
New benzimidazole‐oxadiazole derivatives as potent VEGFR‐2 inhibitors: Synthesis, anticancer evaluation, and docking study
We report herein, the design and synthesis of benzimidazole‐oxadiazole derivatives as new
inhibitors for vascular endothelial growth factor receptor‐2 (VEGFR‐2). The designed …
inhibitors for vascular endothelial growth factor receptor‐2 (VEGFR‐2). The designed …
[HTML][HTML] In silico and in vitro evaluation of novel carbothioamide-based and heterocyclic derivatives of 4-(tert-butyl)-3-methoxybenzoic acid as EGFR tyrosine kinase …
Cancer is an elaborate sequence of disease grades that include uncontrolled cell growth
and division, invasion, and metastasis. Overexpression of the epidermal growth factor …
and division, invasion, and metastasis. Overexpression of the epidermal growth factor …
In vitro and in silico evaluation of 4'-hydroxy-[1, 1'-biphenyl]-4-carbohydrazide Schiff base and oxadiazole derivatives targeting EGFR allosteric site
Inhibition of EGFR tyrosine kinase (TK) activity is considered a promising therapeutic
strategy for cancer treatment. Type I and II EGFR TK inhibitors bind the ATP-binding site …
strategy for cancer treatment. Type I and II EGFR TK inhibitors bind the ATP-binding site …