Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem
involvement. It is multifactorial and involves epigenetic, genetic, ecological, and …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …

Monocytes (Mo) and macrophages (Mϕ) are key components of the innate immune system
and are involved in regulation of the initiation, development, and resolution of many …

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …

The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology
that primarily affects women of childbearing age. The development of SLE is attributed to the …

Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …

Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …