Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

Background: Although thousands of clinical isolates of Plasmodium falciparum are being
sequenced and analysed by short read technology, the data do not resolve the highly …

It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered,
yet its intricacies remain incompletely understood-a knowledge gap that may prove crucial …

Genomic epidemiology has guided research and policy for various viral pathogens and
there has been a parallel effort towards using genomic epidemiology to combat diseases …

Next-generation sequencing (NGS) has become a powerful tool in phylogenetic and
evolutionary studies. Here we applied NGS to recover two ribosomal RNA genes (18S and …

We report an analysis of the propensity of the antimalarial agent cabamiquine, a
Plasmodium-specific eukaryotic elongation factor 2 inhibitor, to select for resistant …