Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease
manifested with not only motor but also non-motor symptoms. In particular, weight loss and …

Background Recent studies increasingly utilize the Movement Disorders Society Sponsored
Unified Parkinson's Disease Rating Scale (MDS-UPDRS). However, the minimal clinically …

The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …

Fatigue is one of the most common and disabling symptoms in Parkinson's disease (PD).
Since fatigue was first described as a common feature of PD 20 years ago, little progress …

Background STN-DBS is well established to improve motor symptoms and quality of life in
patients with PD. While non-motor symptoms are crucial for quality of life in these patients …

Bradykinesia is one of the core motor symptoms of Parkinson's disease (PD). Neurologists
typically perform face-to-face bradykinesia assessment in PD patients according to the …

Background: The objective of this study was to investigate 24‐month of effects of bilateral
subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms in …

Background: The minimal clinically important difference is the smallest change of scores
clinically meaningful to patients. Objectives: We aimed to calculate these threshold values in …

A considerable body of research has recently emerged around nonmotor symptoms in
Parkinson's disease (PD) and their substantial impact on patients' well-being. A prominent …