Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening
Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB)
remains a formidable challenge for central nervous system drug development. High‐fidelity …
remains a formidable challenge for central nervous system drug development. High‐fidelity …
Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …
the development of organ-on-a-chip devices that can reproduce key functions of various …
Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies
S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …
Recent advances in the prediction of pharmacokinetics properties in drug design studies: a review
SQ Pantaleão, PO Fernandes, JE Gonçalves… - …, 2022 - Wiley Online Library
This review presents the main aspects related to pharmacokinetic properties, which are
essential for the efficacy and safety of drugs. This topic is very important because the …
essential for the efficacy and safety of drugs. This topic is very important because the …
Recent advances in drug delivery and targeting to the brain
Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior
Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly
specialized brain microvascular endothelial cells, a major component of the BBB, express …
specialized brain microvascular endothelial cells, a major component of the BBB, express …
The role of shear stress in Blood-Brain Barrier endothelial physiology
Background One of the most important and often neglected physiological stimuli contributing
to the differentiation of vascular endothelial cells (ECs) into a blood-brain barrier (BBB) …
to the differentiation of vascular endothelial cells (ECs) into a blood-brain barrier (BBB) …
In vitro modeling of the neurovascular unit: advances in the field
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …
functional and structural integrity is vital in maintaining the homeostasis of the brain …