Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

Objectives Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine
transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of …

The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …

We have developed a high content 384-well, image-based assay to estimate the effect of
compound treatment on Trypanosoma cruzi amastigotes in 3T3 fibroblasts. In the same well …

Infectious diseases caused by pathogenic protozoa are among the most significant causes
of death in humans. Therapeutic options are scarce and massively challenged by the …

A series of 73 bisphosphonium salts and 10 monophosphonium salt derivatives were
synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma …