The animal trypanosomiases and their chemotherapy: a review
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …
agricultural development in Africa for centuries, and their negative economic impact is …
The drugs of sleeping sickness: their mechanisms of action and resistance, and a brief history
H P. De Koning - Tropical Medicine and Infectious Disease, 2020 - mdpi.com
With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …
towards the WHO goal of eliminating sleeping sickness as a major public health concern …
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans
S Ramakrishnan, M Serricchio, B Striepen… - Progress in Lipid …, 2013 - Elsevier
Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of …
Objectives Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine
transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of …
transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of …
Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites
JJ Nué-Martinez, D Cisneros… - Journal of Medicinal …, 2023 - ACS Publications
The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …
groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three …
Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad …
MA Ungogo, MM Aldfer, MJ Natto, H Zhuang… - International journal of …, 2023 - mdpi.com
African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …
Lipid metabolism in Trypanosoma cruzi: A review
LA Booth, TK Smith - Molecular and biochemical parasitology, 2020 - Elsevier
The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …
[HTML][HTML] Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi …
We have developed a high content 384-well, image-based assay to estimate the effect of
compound treatment on Trypanosoma cruzi amastigotes in 3T3 fibroblasts. In the same well …
compound treatment on Trypanosoma cruzi amastigotes in 3T3 fibroblasts. In the same well …
Targeting channels and transporters in protozoan parasite infections
A Meier, H Erler, E Beitz - Frontiers in chemistry, 2018 - frontiersin.org
Infectious diseases caused by pathogenic protozoa are among the most significant causes
of death in humans. Therapeutic options are scarce and massively challenged by the …
of death in humans. Therapeutic options are scarce and massively challenged by the …
Synthesis and structure–activity analysis of new phosphonium salts with potent activity against African trypanosomes
A Taladriz, A Healy, EJ Flores Perez… - Journal of Medicinal …, 2012 - ACS Publications
A series of 73 bisphosphonium salts and 10 monophosphonium salt derivatives were
synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma …
synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma …