Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials,
chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health …

Drug-resistant mutant forms of an organism are likely to be less fit than their wild-type strains
in the absence of selection. Experimental work on prokaryotic organisms suggests that this …

In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-
pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum …

Background In 1993, Malawi became the first country in Africa to replace chloroquine with
the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time …

This document was prepared for the Roll Back Malaria Department of the World Health
Organization by Pascal Ringwald with the collaboration of Laura Shallcross, who was …

The emergence and spread of drug-resistant parasites poses a major problem for
management of Plasmodium falciparum malaria in endemic areas. Nowhere is this more …

Malaria continues to be a leading cause of death in the tropics, taking the heaviest toll on
children in Africa, where drug resistant Plasmodium falciparum has led to rising malaria …

Background A reversal of chloroquine (CQ) resistance following a period of withdrawal has
raised the possibility of its re-introduction. This study evaluated the current prevalence of …

Malaria, a leading parasitic disease, inflicts an enormous toll on human lives and is caused
by protozoal parasites belonging to the genus Plasmodium. Antimalarial drugs targeting …

Chloroquine (CQ) has been the front line antimalarial drug due to its efficacy, low cost and
scanty side effects, until resistance has evolved. Although its use has been officially …