Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention
has been focused to unravel the mechanisms and optimize the treatment regimens …

Diabetes mellitus is an extremely prevalent endocrine disease and a major global public
health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and …

Background Diabetic nephropathy (DN) is prevalent in patients with diabetes. N 6-
methyladenosine (m6A) methylation has been found to cause modification of nucleotide …

Diabetic nephropathy (DN), which is a common microvascular complication with a high
incidence in diabetic patients, greatly increases the mortality of patients. With further study …

Diabetic kidney disease (DKD) is one of the most common microvascular complication of
both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), and the leading cause of end …

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …

Excessive mitochondrial fission acts as a pro-proliferative marker in some cancers and
organ fibrosis; its potential role in renal fibroblast activation and fibrogenesis has never been …

Type 1 diabetes (T1D) is a chronic autoimmune disorder that leads to progressive
pancreatic ß-cell destruction and culminates in absolute insulin deficiency and stable …