Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Neural stem/precursor cells in the adult brain reside in the subventricular zone (SVZ) of the
lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus …

Neurogenesis in the adult hippocampus involves activation of quiescent neural stem cells
(NSCs) to yield transiently amplifying NSCs, progenitors, and, ultimately, neurons that affect …

Eph receptors constitute the largest family of receptor tyrosine kinases, which are activated
by ephrin ligands that either are anchored to the membrane or contain a transmembrane …

Neural stem and progenitor cells (NSCs and NPs) give rise to the central nervous system
(CNS) during embryonic development. NSCs and NPs differentiate into three main cell-types …

There is increasing evidence that in addition to having major roles in morphogenesis, in
some tissues Eph receptor and ephrin signaling regulates the differentiation of cells. In one …

Multiple cellular components are involved in the complex pathological process following
central nervous system (CNS) injury, including neurons, glial cells and endothelial cells …

The presence of neurogenic precursors in the adult mammalian brain is now widely
accepted, but the mechanisms coupling their proliferation with the onset of neuronal …

Eph: ephrin signaling plays an important role in embryonic development as well as tissue
homeostasis in the adult. At the cellular level, this transduction pathway is best known for its …

Damage to the cerebrovascular network is a major contributor to dysfunction in patients
suffering from traumatic brain injury (TBI). Vessels are composed of lumen-forming …