New frontiers in selective human MAO-B inhibitors: miniperspective

S Carradori, R Silvestri - Journal of medicinal chemistry, 2015 - ACS Publications
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …

Monoamine oxidase inhibitory action of chalcones: A mini review

B Mathew, A Haridas, J Suresh… - … System Agents in …, 2016 - ingentaconnect.com
Introduction: Chalcones are one of the major classes of naturally occurring compounds and
have a vast significance in medicinal chemistry, presenting with a wide scope of …

Pyrazoline: A promising scaffold for the inhibition of monoamine oxidase

B Mathew, J Suresh, S Anbazhagan… - … System Agents in …, 2013 - ingentaconnect.com
In the five membered nitrogen containing heterocyclic family, pyrazoline could be
recognized as a promising scaffold for the inhibition of Monoamine oxidase. Substitution at …

Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors

A Hammuda, R Shalaby, S Rovida… - European journal of …, 2016 - Elsevier
A novel series of substituted chalcones were designed and synthesized to be evaluated as
selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl …

Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies

B Evranos-Aksöz, S Yabanoğlu-Çiftçi, G Uçar… - Bioorganic & medicinal …, 2014 - Elsevier
A novel series of 2-pyrazoline and hydrazone derivatives were synthesized and investigated
for their human monoamine oxidase (hMAO) inhibitory activity. All compounds inhibited the …

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

MC Costas-Lago, P Besada… - European Journal of …, 2017 - Elsevier
Compounds of hybrid structure pyridazine-coumarin were discovered as potent, selective
and reversible inhibitors of monoamine oxidase B (MAO-B). These compounds were …

Recent updates on pyrazoline derivatives as promising candidates for neuropsychiatric and neurodegenerative disorders

TM Rangarajan, B Mathew - Current Topics in Medicinal …, 2021 - ingentaconnect.com
Pyrazolines are five-membered heterocyclic compounds containing two nitrogen atoms that
represent a privileged scaffold for various bioactive compounds with diverse …

[HTML][HTML] Facile synthesis of new pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidin-5(1H)-ones via the tandem intramolecular Pinner–Dimroth rearrangement and their …

N Dorostkar-Ahmadi, A Davoodnia… - … für Naturforschung B, 2019 - degruyter.com
Abstract Some new 7-alkyl-4, 6-dihydropyrazolo [4′, 3′: 5, 6] pyrano [2, 3-d] pyrimidin-5 (1
H)-ones were prepared through heterocyclization of 6-amino-1, 4-dihydropyrano [2, 3-c] …

[PDF][PDF] EXPLORATION OF PYRAZOLINE AND AMINO CHALCONE DERIVATIVES AS MONOAMINE OXIDASE INHIBITORS: AN IN-SILICO APPROACH

NL Sa'adah, MFB Darmawan… - Rasayan Journal of …, 2023 - rasayanjournal.co.in
Monoamine oxidase (MAO) is an enzyme involved in neurotransmitter monoamine
metabolism through an oxidative deamination reaction that produces a nerve-damaging …

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

S Bhavanarushi, ZB Luo, G Bharath… - Journal of …, 2020 - Wiley Online Library
This paper investigates the seismic and collapse performance of shape memory alloy (SMA)
braced steel frame structures considering the effects of various brace design parameters …