Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on
the molecular and cellular mechanisms underlying depression. Here, we review data …

Purpose This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy
of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1) …

As 2 O 3 cures acute promyelocytic leukemia (APL) by initiating PML/RARA oncoprotein
degradation, through sumoylation of its PML moiety. However, how As 2 O 3 initiates PML …

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly
metastatic prostate cancer cells. Here, we identified the functional activities of Runx2 in …

Purpose We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy
of selinexor, an oral selective inhibitor of nuclear export compound, in patients with …

We present cytometric classification of live healthy and cancerous cells by using the spatial
morphological and textural information found in the label‐free quantitative phase images of …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

Runx2, required for bone formation, is ectopically expressed in breast cancer cells. To
address the mechanism by which Runx2 contributes to the osteolytic disease induced by …

This protocol describes a method for nucleocytoplasmic protein tracking during normal cell
cycle progression using unmanipulated, asynchronous cells. In contrast with prevalent …